基礎薬学講座　生物化学部門

生物化学教室は1号館の3階、ちょうど図書館の真上に当たる位置にあります。メンバーは、板部教授、小濱准教授、牧山助教、渡邉助教、大学院生1名、研究生2名、さらに足彩胜负彩4年度の学部生（P4～P6）25名が加わっています。

講座紹介

現在は、まさに薬学の変革期であります。薬学分野全体が医療を担う一員として、研究においても実務においても、社会との接点を積極的に開拓しようとしています。高齢化社会が現実となってきた現在、いわゆる生活習慣病などの疾患に関する理解をより深めることの重要性が高まっています。生物化学部門では、動脈硬化症、メタボリックシンドローム、非アルコール性肝疾患などの疾患に関わる因子の解明を目指して、脂質代謝、炎症、酸化ストレスなどの観点から生化学研究を進めてきました。常に新しい技術、新しい視点を加えて、疾患に迫る薬学研究を展開したいと思います。

教育

生物化学部門では、主に以下の科目の講義、演習、実習を担当しています。

P1後期　生命活動を担う分子(細胞構成因子)
P2前期　生命活動を担う分子(物質輸送とエネルギー産生)
P2前期　生命活動を担う分子(代謝とその調節)
P2後期　生命活動を担う分子(細胞の構造?機能と情報伝達)
P2後期　生命体の成り立ち(実習)
P4前期　生命活動を担う分子(分子?細胞から生理?病態へ)
P4前期　薬学研究入門
P4/5　　実務実習
P5/6　　薬学研究
P5　　　海外での薬剤師の役割を知る

大学院薬学研究科　疾患解明の先端科学
　　　　　　　　　生体高分子の構造解析法

研究

生物化学教室では、現在以下の研究テーマを柱としています。
1）好中球ネトーシスと動脈硬化症
2）細胞内脂肪滴の形成と小胞輸送機構
3）非アルコール性脂肪肝炎（NAFLD）における好中球の関与
4）血漿リポタンパク質の酸化変性の分子論的解析

沿革

1964年に薬学部が設立されて4年目の1967年に、薬学部に2つ目の学科として生物薬学科が増設されました。この時に新たに作られた7つの講座の一つとして、生物化学教室が設置されました。教室開設後、2号館1階、1号館4階と場所を変えましたが、1977年に現在生物化学教室のある1号館3階生化学系教室のブロックに移動して以来、今に至っています。
初代主任教授は、東京工業大学から昭和大学教養部を経て着任した中村泰治先生(教授在任期間1967～1991)です。中村教授は、神経伝達物質の代謝の研究をスタートに、神経細胞の膜タンパク質や情報伝達系の研究に取り組まれました。

1991年中村先生のご定年を受けて、中谷一泰先生が助教授から昇任し二代目の教授として教室を受け継がれました(教授在任期間1991～2004)。中谷先生はがん細胞の研究、とくにがん細胞を特異的にプログラム細胞死に導く種々の薬物を見出され、またそれらのユニークなアポトーシス誘導機構に関して研究を進められました。

現在の板部洋之教授(教授在任期間2004～)は、現代人の健康を脅かしている動脈硬化症やメタボリックシンドロームの基盤となる、リポタンパク質の酸化変性、細胞レベルでの脂質代謝?蓄積のしくみ、細胞内脂肪滴と脂質代謝制御についての研究を進めています。2017年には中谷教授の喜寿のお祝いを兼ねて同窓会を開き、中村名誉教授をはじめ多くの超える卒業生?旧教職員が旧交を温め、また6年制で学ぶ後輩を紹介しました。

2006年薬学部6年制、2012年からは4年制大学院博士課程が始まりました。薬学教育制度の移行とともに、医療に貢献する薬学研究がますます強く求められる時代になりました。生物化学部門では、学部生?大学院生と共に医療に貢献する生化学研究を目指し、医学部、歯学部との共同研究にも積極的に取り組んでいます。

講座員

教員（専任）

役職氏名name
教授板部 洋之Itabe Hiroyuki
准教授小濵 孝士Obama Takashi
助教牧山 智彦Tomohiko Makiyam
助教渡邉 雄一Yuichi Watanabe

研究業績


すべて開く　＋

2021年業績

英文原著論文?総説

Itabe H,Sawada N, Makiyama T, , Obama T.: Structure and dynamics of oxidized lipoproteins in vivo: roles of high-density lipoproteins. Biomedicines, 2021, 93:655.

Phimarn W, Suntag B, Itabe H.: Effects of triphala to improve lipid profile and blood glucose and anthropometric parameters. A systemic review. J. Evidence-based Integr. Med. 2021, 26:2515690X21101038.

Kato S, Osuka Y, Khalifa S, obama T, Itabe H, Nakagawa K.: Investigation of lipoproteins oxidation mechanisms by the analysis of hydroperoxide isomers. Antioxidants 2021, 10:1598

和文総説

板部洋之：　動脈硬化の発症?進展に関わる酸化変性リポタンパク質　　昭和大学学士会雑誌（2021）81：370-379

2020年業績

英文原著論文?総説

Odanaka H, Obama T, Sawada N, Sugano M, Itabe H, Yamamoto M.: Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins. Biol. Res., 2020, 53:3.

Sawada N, Obama T, Koba S, Takaki T, Iwamoto S, Aiuchi T, Kato R, Kikuchi M, Hamazaki Y, Itabe H.: Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL. J. Lipid Res. 2020, 61:819-929.

Sawada N, Obama T, Mizuno M, Fukuhara K, Iwamoto S, Aiuchi T, Makiyama T, Itabe H.: Transfer and enzyme-mediated metabolism of oxidized phosphatidylcholine and lysophosphatidylcholine between low- and high-density lipoproteins. Antioxidants 2020, 9:1045

Obama T, Itabe H.: Neutrophils as a novel target of modified low-density lipoproteins and an accelerator of cardiovascular diseases. Int. J. Mol. Sci. 2020,21:8312. (review)

Shimamura H, Katsuragi S, Yoshikawa M, Nakura M, Sasaki T, Itabe H.: Standard pharmacist intervention checklist to improve the appropriate use of medications for inpatients with polypharmacy. BPB Rep. 2020, 3:196-201.

2019年業績

英文原著論文?総説

Obama T, Miyazaki T, Aiuchi T, Miyazaki A, Itabe H.: A simple method for the evaluation of protein–protein interactions using an on-membrane digestion technique. J. Vis. Exp., 2019, Issue 149:e59733.

Obama T, Ohinata H, Takaki T, Iwamoto S, Sawada N, Aiuchi T, Kato R, Itabe H.: Cooperative action of oxidized low-density lipoproteins and neutrophils on endothelial inflammatory responses through neutrophil extracellular trap formation. Front. Immun., 2019, 10:1899.

Kawata N, Kang D, Aiuchi T, Obama T, Shibata T, Murakami M, Takimoto M, Itabe H, Honda K.: Title: Proteomics of human glomerulonephritis by laser microdissection and liquid chromatography-tandem mass spectrometry. Nephrology, 2019, 25:351-359.doi: 10.1111/nep.13676.

Uekita H, Ishibashi T, Shiomi M, Koyama H, Ohtsuka S, Yamamoto H, Yamagishi S, Inoue H, Itabe H, Sugimoto K, Kamioka M, Ohkawara H, Wada I, Yasuchika T.: Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis. Fukushima J. Med. Sci. 2019;65:109-121.

Kato R, Hayashi M, Aiuchi T, Sawada N, Obama T, Itabe H.: Temporal and spatial changes ofperoxiredoxin2 levels in aortic media at very early stages of atherosclerotic lesion formation in apoE-knockout mice. Free Rad. Biol. Med., 2019; 130:348-360.

Takemaru M, Sawada N, Aiuchi T, Itabe H, Yamamoto M.: Comparison of protein profiles of gingival crevicular fluids collected from incisors, canines and molars. Showa Univ. J. Med. Sci., 2019, 31:365-372.

Itabe H, Kato R, Sasabe N, Obama T, Yamamoto M.: Significance of oxidized low-density lipoprotein in body fluids as a marker related to diseased conditions. Curr. Med. Chem. 2019, 26:1576-1593. (review)

和文総説

小濱孝士、板部洋之：　動脈硬化とNETs 酸化LDLとの相乗作用　　Thrombosis Medicine（2019）9：285-291

2018年業績

英文原著論文?総説

Shimamura H, Yamada H, Okada N, Uchikura T, Tanaka K, Sasaki T, Itabe H.: A standard intervention practice to promote appropriate lamotrigine therapy by pharmacists. Biol. Pharm. Bull. 2018, 41(4):465-469.

Kuwata H, Yuzurihara C, Kinoshita N, Taki Y, Ikegami Y, Washio S, Hirakawa Y, Yoda E, Aiuchi T, Itabe H, Nakatani Y, Hara S.: The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1beta-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts. FEBS J. 2018:285(11):2056-2070.

Ning B, Chen Y, Waqar AB, Yan H, Shiomi M, Zhang J, Chen TE, Wang Y, Itabe H, Liang J, Fan J.: Hypertension enhances advanced atherosclerosis and induces cardiac death in Watanabe heritable hyperlipidemic rabbits. Am. J. Pathol. 2018 188:2936-2947.

和文総説

笹部直子、板部洋之：　Lp-PLA2と変性リポタンパク質の代謝　臨床化学　(2018)　47：128-135

2017年業績

英文原著論文?総説

Ishizuka M, Kato R, Moriya Y, Noguchi E, Koide Y, Inoue S, Itabe H, Yamamoto M.: Changes in apolipoprotein B and oxidized low-density lipoprotein levels in gingival crevicular fluids caused by periodontal tissue conditions. J. Periodont. Res. 2017, 52:594-602.

Moriya Y, Obama T, Aiuchi T, Sugiyama T, Endo Y, Koide Y, Noguchi E, Ishizuka M, Inoue M, Itabe H, Yamamoto M.: Quantitative proteomic analysis of gingival crevicular fluids from deciduous and permanent teeth. J. Clin. Periodontol. 2017, 44:353-362.

Yamada S, Koike T, Nakagawa T, Kuniyoshi N, Ying Y, Itabe H, Yamashita A, Asada Y, Shiomi M.: Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia. Experimental Animals. 2017, 66:145-157.

Forrester SJ, Elliott KJ, Kawai T, Obama T, Boyer MJ, Preston KJ, Yan Z, Eguchi S, Rizzo V.: Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II. Hypertension. 2017, 69:79-86.

Itabe H, Yamaguchi T, Nimura S, Sasabe N. Perilipins: A diversity of intracellular lipid droplet proteins. Lipids Health Dis. 2017, 16:83. (review)

2016年業績

英文原著論文?総説

Kurosawa T, Yamada A, Suzuki D, Morimura N, Sasagane Y, Itabe H, Kamijo R.:
Nephronectin expression is up-regulated by BMP-2. Biol. Pharm. Bull. 2016, 39:1211-1215.

Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei X-F, Kim-Kaneyama J, Takeya M, Itabe, H, Sorimachi H, Kurihara H, Miyazaki A.: Disturbance of pre-mRNA splicing by calpain-6 aggravates pinocytotic cholesterol deposition in macrophages. J. Clin. Invest.
2016, 126:3417-3432.

2015年業績

英文原著論文?総説

Takayanagi T, Kawai T, Forrester SJ, Obama T, Tsuji T, Fukuda Y, Elliott KJ, Tilley DG, Davisson RL, Park JY, Eguchi S.: Role of Epidermal Growth Factor Receptor and Endoplasmic Reticulum Stress in Vascular Remodeling Induced by Angiotensin II. Hypertension. 2015 65:1349-1355.

Arita-Okubo S, Kim-Kaneyama JR, Lei XF, Fu WG, Ohnishi K, Takeya M, Miyauchi A, Honda H, Itabe H, Miyazaki T, Miyazaki A.: Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis. Cardiovasc. Res. 2015,

Keyamura Y, Nagano C, Kohashi M, Niimi M, Nozako M, Koyama T, Itabe H, Yoshikawa T.: Dietary-cholesterol atherogenesis drastically changed during the juvenile period in rabbits. Biol. Pharm. Bull. 2015, 38:785-788.

Kurosawa T, Yamada A, Takami M,Suzuki D, Saito Y, Hiranuma K, Enomoto T, Morimura N, Yamamoto M, Iijima T, Shirota T, Itabe H, Kamijo R.: Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways. FEBS Open Bio. 2015, 5:303-307.

Obama T, Tsuji T, Kobayashi T, Fukuda Y, Takayanagi T, Taro Y, Kawai T, Forrester SJ, Elliott KJ, Choi E, Daugherty A, Rizzo V, Eguchi S.: Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model. Clin. Sci. (Lond). 2015, 128:559-565.

Yamaguchi T, Fujikawa N, Nimura S, Tokuoka Y, Tsuda S, Aiuchi T, Kato R, Obama T, Itabe H.: Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation. BBA - Molecular and Cell Biology of Lipids, 2015, 1851:1285-1295.

Obama T, Takayanagi T, Kobayashi T, Bourne AM, Elliott KJ, Charbonneau M, Dubois CM, Eguchi S.: Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1α. Am J Hypertens. 2015, 28:10-14.

Nimura S, Yamaguchi T, Ueda K, Kadokura K, Aiuchi T, Kato R, Obama T, Itabe H.: Olanzapine promotes the accumulation of lipid droplets and the expression of multiple perilipins in human adipocytes. Biochem. Biophys. Res. Commun. 2015, 467: 906-912.

2014年業績

英文原著論文?総説

Noguchi E, Kato R, Ohno K, Mitsui A, Obama T, Hirano T, Itabe H, Yamamoto M.: The apolipoprotein B concentration in gingival crevicular fluid increases in patients with diabetes mellitus. Clin. Biochem. 2014, 47:67-71.

Takayanagi T, Crawford KJ, Kobayashi T, Obama T, Tsuji T, Elliott KJ, Hashimoto T, Rizzo V, Eguchi S.: Caveolin-1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyloxidase. Clin. Sci. (Lond). 2014, 126:785-794.

Sasabe N, Keyamura Y, Obama T, Inoue N, Masuko Y, Igarashi Y, Aiuchi T, Kato R, Yamaguchi T, Kuwata H, Iwamoto S, Miyazaki A, Hara S, Yoshikawa T, Itabe H.: Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein. Lipids Health Dis. 2014, 13:48

Keyamura Y, Nagano C, Kohashi M, Niimi M, Nozako M, Koyama T, Yasufuku R, Imaizumi A, Itabe H, Yoshikawa T: Add-on effect of probucol in atherosclerotic, cholesterol-fed rabbits treated with atorvastatin. PLoS ONE, 2014, 9: e96929.

Lei XF, Kim-Kaneyama JR, Arita-Okubo S, Offermanns S, Itabe H, Miyazaki T, Miyazaki A.: Identification of Hic-5 as a Novel Scaffold for the MKK4/p54 JNK Pathway in the Development of Abdominal Aortic Aneurysms. J. Am. Heart Assoc. 2014, 3:e000747.

2013年業績

英文原著論文?総説

Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.: Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in autopsy samples from Japanese elders: the Hisayama Study. Kidney Int. 2013, 84:373-380.

Kitabayashi C, Naruko T, Sugioka K, Yunoki K, Nakagawa M, Inaba M, Ohsawa M, Konishi Y, Imanishi M, Inoue T, Itabe H, Yoshiyama M, Haze K, Becker AE, Ueda M.: Positive association between plasma levels of oxidized low-density lipoprotein and myeloperoxidase after hemodialysis in patients with diabetic end-stage renal disease. Hemodial Int. 2013, 17:557-567.

Nose F, Yamaguchi T, Kato R, Aiuchi T, Obama T, Hara S, Yamamoto M, Itabe H.: Crucial role of perilipin-3 (TIP47) in formation of lipid droplets and PGE2 Production in HL-60-derived neutrophil. PLoS ONE, 2013, 8: e71542.

2012年業績

英文原著論文?総説

Kawakami Y, Hosokawa T, Morinaka T, Irino S, Hirano S, Kobayashi H, Yoshioka A, Suzuki-Yamamoto T, Yokoro M, Kimoto M, Tsuji H, Yamashita H, Doi S, Yutani C, Kato R, Itabe H, Kanada T, Hada T, Takahashi Y.: Antiatherogenic effect of guava leaf extracts inhibiting leukocyte-type 1 12-lipoxygenase activity. Food Chem. 2012, 131: 1069?1075.

Suzuki M, Tsujikawa M, Itabe H, Du Z-J, Xie p, Matsumura N, Fu X, Zhang R, Sonoda K, Egashira K, Hazen SL, Kamei M: Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration. J. Cell Sci. 2012, 125:2407-2415.

Dong S, Furutani Y, Suto Y, Furutani M, Zhu Y, Yoneyama M, Kato T, Itabe H, Nishikawa T, Tomimatsu H, Tanaka T, Kasanuki H, Masaki T, Kiyama R, Matsuoka R.: Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract. Microbiol. Res. 2012, 167:231-237.

Tamura H, Ohgami N, Yajima I, Iida M, Ohgami K, Fujii N, Itabe H, Kusudo T, Yamashita H, Kato M.: Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice". PLoS ONE, 2012, 7: e39807

Kuramoto K, Okamura T, Yamaguchi T, Nakamura TY, Wakabayashi S, Morinaga H, Nomura M, Yanase T, Otsu K, Usuda N, Matsumura S, Inoue K, Fushiki T, Kojima Y, Hashimoto T, Sakai F, Hirose F, Osumi T.: Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. J. Biol. Chem. 2012, 287:23852-23863.

Hashimoto T, Segawa H, Okuno M, Kano H, Hamaguchi HO, Haraguchi T, Hiraoka Y, Hasui S, Yamaguchi T, Hirose F, Osumi T.: Active involvement of micro-lipid droplets and lipid-droplet-associated proteins in hormone-stimulated lipolysis in adipocytes. J Cell Sci. 2012, 125:6127-6136.

Itabe H.: Oxidized low-density lipoprotein as a biomarker of in vivo oxidative stress: from atherosclerosis to periodontitis. J. Clin. Biochem. Nutr. 2012, 51:1-8

2011年業績

英文原著論文?総説

Shibata T, Shimozu Y, Wakita C, Shibata N, Kobayashi M, Machida S, Kato R, Itabe H, Zhu X, Sayre LM, Uchida K.: Lipid peroxidation modification of protein generates Nε-(4-oxononanoyl)lysine as a pro-inflammatory ligand. J. Biol. Chem. 2011, 286:19943-19957.

Koyama S, Ohtani K, Fukuzawa J, Yao N, Fukuda M, Jang SJ, Hasebe N, Kikuchi K, Itabe H, Yoshida I, Suzuki Y, Wakamiya N.: The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment. Biochim Biophys Acta. 2011, 1810:836-842.

Obama T, Nagaoka S, Akagi K, Kato R, Horiuchi N, Horai Y, Aiuchi T, Arata S, Yamaguchi T, Watanabe M, Itabe H.: Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: Suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway. PLoS ONE, 2011, 6:e22917

Nagahama Y, Obama T, Usui M, Kanazawa Y, Iwamoto S, Suzuki K, Miyazaki A, Yamaguchi T, Yamamoto M, Itabe H.: Oxidized low-density lipoprotein-induced periodontal inflammation is associated with up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells. Biochem. Biophys. Res. Commun. 2011, 413:566-571.

Wang Z-Y, Miki T, Ding Y, Wang S-J, Gao Y-H, Wang X-L, Wang Y-H, Yokoyama T, Warita K, Ohta K, Suzuki S, Ohnishi T, Obama T, Bedi KS, Takeuchi Y, Shan B-E.: A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus. Metab. Brain Dis. 2011, 26:185?194

Wang H, Bell M, Sreenevasan U, Hu H, Liu J, Dalen K, Londos C, Yamaguchi T, Rizzo MA, Coleman R, Gong D, Brasaemle D, Sztalryd C.: Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J. Biol. Chem. 2011 May 6;286:15707-15

Itabe H, Obama T, Kato R.: The dynamics of oxidized LDL during atherogenesis. J. Lipids. 2011, Article ID 418313:1-9.　（Review）

2010年業績

英文原著論文?総説

Sakiyama Y, Kato R, Inoue S, Suzuki K, Itabe H, Yamamoto M.: Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patients J. Periodont. Res. 2010, 45:216-222

Hoshino S, Konishi M, Mori M, Shimamura M, Nishitani C, Kuroki Y, Koyanagi Y, Kano S, Itabe H, Ishizaka Y.: HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency. J. Leukocyte Biol. 2010, 87(6):1133-1143.

Suzuki K, Sakiyama Y, Usui M, Obama O, Kato R, Itabe H, Yamamoto M.: Oxidized low-density lipoproteins increases IL-8 production in human gingival epithelial cell line Ca9-22. J. Periodont. Res. 2010, 45:488-195.

Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H.: Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver. J Lipid Res. 2010, 51(9): 2571-2580.

Yamaguchi T.: Crucial role of CGI-58/α/β hydrolase domain-containing protein 5 in lipid Metabolism. Biol. Pharm. Bull. 2010, 33(3):342-345. (Review)

2009年業績

英文原著論文?総説

Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, Itabe H.: Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice. Arterioscler. Thromb. Vasc. Biol. 2009, 29(1):33-39.

Komi Y, Suzuki Y, Shimamura M, Kajimoto S, Nakajo S, Masuda M, Shibuya M, Itabe H, Shimokado K, Oettgen P, Nakaya K, Kojima S.: Mechanism of inhibition of tumor angiogenesis by β-hydroxyisovalerylshikonin. Cancer Science, 2009, 100(2):269-277.

Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R.: IFN-γ down-regulates secretoglobin 3A1 gene expression. Biochem. Biophys. Res. Commun. 2009, 379:964-968

Itabe, H.: Circulating Oxidized Lipoproteins and Cardiovascular Risk. Cur. Cardiovasc. Risk Rep. (2009) 3:18-22.　 (Review)

Nishihira K, Imamura T, Ishikawa T, Yamashita A, Shibata Y, Itabe H, Kitamura K, Asada Y.: Interleukin-10 correlates with oxidized low density lipoprotein in coronary culprit plaques. Thromb. Res. 2009, 124:335-337.

Wang H, Hu L, Dalen K, Dorward H, Marcinkiewicz A, Russell D, Gong D, Londos C, Yamaguchi T, Holm C, Rizzo MA, Brasaemle D, Sztalryd C.: Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J. Biol. Chem. 2009, 284:32116-32125

Suzuki K, Takahashi K, Nishimaki-Mogami T, Kagechika H, Yamamoto M, Itabe H.: Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells. Biol. Pharm. Bull. 2009, 37:1177-1182.

Shibata N, Toi S, Shibata T, Uchida K, Itabe H, Sawada T, Kawamata T, Okada Y, Uchiyama S, Kobayashi.M.: Immunohistochemical detection of 13(R)-hydroxyoctadecadienoic acid in atherosclerotic plaques of human carotid arteries using a novel specific antibody. Acta Histochem. Cytochem. 2009, 42:197-203

Fujii H, Ikura Y, Arimoto J, Sugioka K, Iezzoni JC, Park SH, Naruko T, Itabe H, Kawada N, Caldwell SH, Ueda M.: Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. J Atheroscler. Thromb. 2009, 16(6):893-901.

Itabe H: Oxidative modification of LDL: Its pathological role in atherosclerosis. Clin. Rev. Allegy Immunol. 2009, 37:4-11. (Review)

和文総説?著書

板部洋之：酸化LDLとその受容体　血管医学　(2009) 10, 11-16

板部洋之：血漿酸化LDL　「コレステロール---基礎から臨床へ---」（寺本民夫　編）
pp.113-116 (2009) ライフサイエンス出版、東京

2008年業績

英文原著論文?総説

Kajimoto S, Horie M, Manabe H, Masuda Y, Shibayama-Imazu T, Nakajo S, Xiang FG, Obama T, Itabe H ,Nakaya K.: A tyrosine kinase inhibitor, β-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity. BBA-Mol. Basis Dis.2008; 1782 (1): 41-50

Kono N, Inoue T, Yoshida Y, Sato H, Matsusue T, Itabe H, Niki E, Aoki J, Arai H.: Protection against oxidative stress-induced hepatic injury by intracellular type II PAF-acetylhydrolase by metabolism of oxidized phospholipids in vivo. J. Biol. Chem. 2008:283 (3):1628-1636

Sibayama-Imazu T, Fujisawa Y, Masuda Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K.: Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase the in level of TR3/Nur77 and its accumulation in mitochondria and nuclei. J. Can. Res. Clin. Oncol. 2008, 134(7):803-812

Taketa K, Matsumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T, Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.: Ox-LDL activates PPARalpha and PPARgamma through MAPK-dependent COX-2 expression in macrophages. J. Biol. Chem. 2008, 283(15):9852-9862

Shiomi, M., Yamada, S.; Matsukawa, A., Itabe, H., Ito, T.: Invasion of atherosclerotic plaque into tunica media causes coronary outward remodeling in WHHLMI rabbits. Atherosclerosis, 2008;198:287-293.

Ehara S, Naruko T, Shirai N, Itoh A, Hai E, Sugama Y, Ikura Y, Ohsawa M, Okuyama T, Shirai N, Yamashita H, Itabe H, Haze K, Yoshiyama M, Ueda M. Small coronary calcium deposits and elevated plasma levels of oxidized Low Density Lipoprotein are Characteristic of Acute Myocardial Infarction. J. Atheroscler. Thromb. 2008;15(2):75-81.

Sato H, Kato R, Isogai Y, Saka G, Ohtsuki M, Taketomi Y, Yamamoto K, Tsutsumi K, Yamada J, Masuda S, Ishikawa Y, Ishii T, Kobayashi T, Ikeda K, Taguchi R, Hatakeyama S, Hara S, Kudo I, Itabe H, and Murakami M.: Analyses of group III secreted phospholipase A2 transgenic mice reveals potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell Formation, and atherosclerosis. J. Biol. Chem. 283(48):33483-33497

Shiraishi Y, Watanabe T, Suguro T, Nagashima M, Kato R, Hongo S, Itabe H, Miyazaki A, Hirano T, Adachi M. Chronic urotensin II infusion enhances macrophage foam cell formation and atherosclerosis in apolipoprotein E-knockout mice. J. Hypertens. 2008 Oct;26(10):1955-1965.

Imazu M, Ono K, Tadehara F, Kajiwara K, Yamamoto H, Sumii K, Tasaki N, Oiwa J, Shimohara Y, Gomyo Y, Itabe H.: Plasma levels of oxidized low density lipoprotein are associated with stable angina pectoris and modalities of acute coronary syndrome. Int. Heart J. 2008, Sep;49(5):515-524.

和文総説?著書

小浜孝士、板部洋之：　グリケーション　「酸化ストレスの医学」 pp.123-130 (2008) 診断と治療社、東京

加藤里奈、板部洋之：血漿酸化LDLと動脈硬化の発症?進展　　Angiology Frontier (2008) 7, 25-30