基礎薬学講座 生物物理化学部門

講座紹介

薬品物理化学教室は、本学部開設の翌年1965年7月に追加設置され、初代教室主任の松村教授は糖質化学を研究され、1992年3月に退任。1992年10月に中村が長岡技術科学大学より着任しました。
東京大学薬学部や前任大学におけるのと同様に、生体高分子(特にタンパク質)の立体構造をX線結晶構造解析法により明らかにする研究を行っております。

講座員

教員(専任)

役職氏名name
教授合田 浩明Gouda Hiroaki
助教渡邉 友里江Watanabe Yurie
准教授
早川 大地Hayakawa Daichi

研究業績


2024年業績
Molecular Interaction Fields Describing Halogen Bond Formable Areas on Protein Surfaces
D. Hayakawa, Y. Watanabe, H. Gouda, J. Chem. Inf. Model, 2024, 15, 6003-6013.

2006年業績

生体高分子の構造解析

Crystallization and Preliminary X-Ray Crystallographic Analysis of Yeast Tyrosyl-tRNA Syntheses Complexed with Its Cognate tRNA Kusakabe Y., Ohno S., Tnaka N., Nakamura M., Tsunoda M., Moriguchi T., Asai N., Sekine M., Yokogawa T., Nishikawa K. & Nakamura K.T. Protein Peptide Lett. 13, 417-419 (2006).

Crystal Structures of Mouse Autocrine Motility Factor in Complkex with Carbohydrate Phosphate inhibitors Provide Insight into Structure-Activity Relationship of the Inhibitors Tanaka N., Haga A., Naba N., Shiraiwa K., Kusakabe Y., Hashimoto K., Funasaka T., Nagase H., Raz A.& Nakamura K.T. J. Mol. Biol. 356, 312-324 (2006).

The Autocrine Motility Factor (AMF) and AMF-receptor Combination Needs Sugar Chain Recognition Ability and Interaction Usingthe C-terminal Region of AMF Haga A., Tanaka N., Funasaka T., Hashimoto K., Nakamura K.T., Watanabe H., Raz A. & Nagase H. J. Mol. Biol. 358, 741-753 (2006).

2005年業績

生体高分子の構造解析

Functional Characterization of 2',5'-Linked Oligoadenylate Binding Determinant of Human RNase L Nakanishi M., Tanaka N., Mizutani Y., Mochizuki M., Ueno Y., Nakamura K.T. & Kitade Y.J. Biol. Chem. 280, 41694-41699 (2005)

Molecular basis for recognition of 2',5'-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L Tanaka, N., Nakanishi, M., Kusakabe, Y., K., Goto Y., Kitade, Y., & Nakamura, K.T. Nucleic Acids Symp. Ser. 49, 323-324 (2005).

Mutational analyses of Plasmodium falciparum and human S-adenosylhomocysteine hydrolases Nakanishi M., Yabe S., Tanaka N., Ito Y., Nakamura K.T. & Kitade Y. Mol Biochem Parasitol 143, 146-151 (2005)

Crystallization of the N-Terminal Ankyrin Repeat Domain of the 2-5A-Dependent Endoribonuclease, RNase L Tanaka N., Nakanishi M., Kusakabe Y., Goto Y., Kitade Y. & Nakamura K.T. Protein Peptide Lett. 12, 387-389 (2005).

2004年業績

生体高分子の構造解析

Crystal structure of creatininase reveal the substrate-binding site and provide an insight into the catalytic mechanism Yoshimoto, T., Tanaka, N., Kanada, N., Inoue, T., Haratake, M., Nakamura, K.T., Yue, X., & Ito, K. J. Mol. Biol. 337, 399-416 (2004).

Crystallization and preliminary X-ray crystallographic analysis of Plasmodium falciparum S-adenosyl-L-homocycteine hydrolase Tanaka, N., Kusakabe, Y., Shiraiwa, K., Sakamoto, Y., Nakanishi, M., Kitade, Y., & Nakamura, K.T. Protein Peptide Lett. 11, 201-205 (2004).

Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum. Tanaka, N., Nakanishi, M., Kusakabe, Y., Shiraiwa, K., Yabe, S., Ito, Y., Kitade, Y., & Nakamura, K.T. J. Mol. Biol. 343, 1007-1017 (2004).

Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L. Tanaka, N., Nakanishi, M., Kusakabe, Y., Goto, Y., Kitade, Y., & Nakamura, K.T. EMBO J. 23, 3929-3938 (2004).

Crystallization and preliminary X-ray crystallographic studies of mouse autocrine motility factor. Naba, N., Tanaka, N., Shiraiwa, K., Kusakabe, Y., Funasaka, T., Haga, A., Nagase, H., Raz, A., & Nakamura, K.T. Acta Crystallogr. Section D60, 2084-2086 (2004).

Crystallization and preliminary X-ray crystallographic studies of human 2‘,3’-cyclic-nucleotide 3'-phosphodiesterase. Sakamoto, Y., Tanaka, N., Ichimiya, T., Kurihara, T., & Nakamura, K.T. Acta Crystallogr. Section D60, 2095-2097 (2004).

Three-dimensional structure of the ternary complex of yeast tyrosyl-tRNA synthetase. Tsunoda, M., Kusakabe, Y., Tanaka, N., Ohno, S., Nakamura, M., Senda, T., Sekine, M., Yokogawa, T., Nishikawa, K., & Nakamura, K.T. Nucleic Acids Symp. Ser. 48, 155-156 (2004).

Three-dimensional structure of a cyclic-nucleotide phosphodiesterase from human brain. Sakamoto, Y., Tanaka, N., Ichimiya, T., Kurihara, T., & Nakamura, K.T. Nucleic Acids Symp. Ser. 48, 157-158 (2004).

Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum. Tanaka, N., Nakanishi, M., Kusakabe, Y., Shiraiwa, K., Yabe, S., Ito, Y., Kitade, Y., & Nakamura, K.T. Nucleic Acids Symp. Ser. 48, 281-282 (2004).

Structural study of the archaeal homologous recombinant protein complexed with DNA fragments C. Naoe, M. Tsunoda and K.T. Nakamura Nucleic Acids Symposium Series, 48:115-116.2004

Structural significances of pseudouridination and methylation of uridine residues in tRNA: X-ray analyses of DNA dodecamers containing uridine and pseudouridine I. Koike, S. Naito, W. Adachi, M. Tsunoda, A. Ono and A. Takenaka Nucleic Acids Symposium Series, 48:253-254.2004

その他

Schiff base formation between 5-formyl-2’-deoxy-uridine and lysineε-amino group at monomer and oligomer levels A. Kittaka, C. Horii, H. Tanaka, T. Miyasaka, K.T. Nakamura, R. Kuroda, and T. Sugiyama Heterocycles, 64, 367-382(2004).

Crystal structure of 1,10-dibromodecane and its infrared intensity in a urea clathrate and in the crystal Isao Kanesaka, Sachie Matsuzawa, Ysutomu Ishioka, Yasuyuki Kitagawa, Keiichi Ohno Spectrochimica Acta, A60, 2621-2626(2004).